Plenary paper Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study
نویسندگان
چکیده
1Inserm, U1043, Centre de Physiopathologie de Toulouse Purpan, Section Dynamique Moléculaire des Interactions Lymphocytaires, Toulouse, France; 2Université Toulouse III Paul-Sabatier, Toulouse, France; 3Service d’Anatomie et Cytologie Pathologiques, Centre Hospitalier Universitaire (CHU) Purpan, Toulouse, France; 4Inserm, U858, Université Toulouse III Paul-Sabatier, Toulouse, France; 5Plateau technique d’histopathologie expérimentale, CHU Purpan, Toulouse, France; 6Plateau technique imagerie cellulaire, CHU Purpan, Toulouse, France; 7Istituto di Anatomia Patologica and 8Ematologia, Università Cattolica del Sacro Cuore, Rome, Italy; 9Inserm, U1037, Centre de Physiopathologie de Toulouse Purpan, Immunité innée et hémopathies malignes, Toulouse, France; and 10Service d’Hématologie Clinique, CHU Purpan, Toulouse, France
منابع مشابه
Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study.
CD8+ CTLs are thought to play a role in the control of follicular lymphoma (FL). Yet, the link between CTL tissue distribution, activation status, ability to kill FL cells in vivo, and disease progression is still elusive. Pretreatment lymph nodes from FL patients were analyzed by IHC (n = 80) or by 3-color confocal microscopy (n = 10). IHC revealed a rich infiltrate of CD8+ granzyme B+ (GrzB) ...
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